The HPMI Scientific Advisory Board Meeting is a meeting to interact with the HPMI Team, Scientific Advisory Board and NIH Program Officials, to learn about current research updates and receive feedback. This meeting is open to HPMI Center members and participating labs only.

AGENDA:

Continental Breakfast available at 8:15 

9:00 - 9:15: Overview of Systems Biology for Infectious Diseases Consortium: Keehwan Kwon, (NIH/NIAID) 

9:15 - 9:30: Overview of the HPMI Center: Nevan Krogan [15 mins]

PROJECT 1

9:30 - 9:35: Project 1 Overview: Jeffrey Cox [5 mins]

9:35 - 9:55: Human iPSC Derived Macrophages Are a Genetically Tractable Model of M. tuberculosis Pathogenesis: Michael Glickman [15 mins 5 mins for questions]

9:55 - 10:15: Immunogenetics, Phosphoproteomics, Macrophages & TB Pathogenesis: Thomas Hawn [15 mins 5 mins for questions]

10:15 - 10:35: Using genetic screening to investigate inflammatory signaling during Mycobacterium tuberculosis infection of macrophages: Allison Roberts, Cox Lab [15 mins 5 mins for questions]  

10:35 - 10:50: Coffee Break [15 mins]

PROJECT 2

10:50 - 10:55: Project 2 Overview: Melanie Ott [5 mins]

10:55 - 11:15: Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a: Jennifer Hayashi, Ott Lab [15 mins 5 mins for questions]

11:15 - 11:35: Birth of protein folds and functions in the virome: Jason Nomburg, Doudna Lab [15 mins 5 mins for questions]

11:35 - 11:55: Mapping Host-Viral Dependency Networks to Decode Respiratory Infections: Jyoti Batra, [15 mins 5 mins for questions] 

11:55 - 12:20: Photo break [25 mins]

12:20 - 2:20: Lunch & Museum Tour [2 hours]

TECHNOLOGY CORE

 2:20 - 2:35: Improvements to proteomic workflows for phosphorylation analysis: Danielle Swaney [10 mins 5 mins for questions]

 2:35 - 2:50: Structural studies of SARS CoV2 Nsp2 and Rap1GDS1 complex: Kliment Verba [10 mins 5 mins for questions]

BIOINFORMATICS CORE

2:50 - 3:10: AI Agent Hypotheses from Host-Pathogen Data: How Do We Define “Good”?: Dexter Pratt [15 mins 5 mins for questions]

MODELING CORE

3:10 - 3:25: Using integrative modeling to bridge the gap between systems biology and structure biology: Surabhi Rathore [10 mins 5 mins for questions]

3:25 - 3:40: Integrative Network Modeling - a method to infer physical protein interaction networks from AP-MS data: Aji Palar [10 mins 5 mins for questions]

3:40 - 4:00: Coffee Break [20 mins]

4:00 - 5:00: Poster session [1 hour] View abstracts

In parallel:

 4:00 - 4:30: Advisory Session (closed door: SAB & NIH/NIAID only) [30 mins]

 4:30 - 5:00: Session with HPMI Investigators, Advisory Board and NIH/NIAID [30 mins]

 5:00 - 8:00: Faculty and SAB members Dinner at China Live

Join the meeting via zoom: https://ucsf.zoom.us/j/95283922704?pwd=cGRZdnNEeWl2SUZEenJiSThQalpWQT09

Meeting ID: 952 8392 2704
Password: 327210