HPMI scientists employ CRISPR/Cas9-based genetic screening methodologies to systematically identify the gene networks that underlie pathogenesis in clinically relevant model systems of infections with important bacterial pathogens.
Read moreCryo-EM has undergone a recent "resolution revolution" that is bringing ever higher resolution pictures into focus of highly complex and dynamic systems that would previously have been intractable.
Read moreComputational biologists aim to address fundamental and applied questions in biology and biomedicine, by analyzing and modeling biological datasets using sophisticated theoretical and computational techniques.
Read moreThe QBI collaboration, through the Gladstone Institute and the Convergence Zone, is home to a collection of premier mass spectrometers. We specialize in large-scale protein-protein interaction mapping via affinity purification mass spectrometry (AP-MS), with an emphasis on host-pathogen interactions.
Read moreWe are developing model systems that can advance understanding of infectious diseases.
Read moreX-ray crystallography is a powerful method to derive protein structural information. Pure proteins can be coaxed into forming beautiful crystals.
Read more
.jpg)
